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A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum
- Source :
- Molecules, Volume 19, Issue 11, Pages 17839-17847, Molecules, Vol 19, Iss 11, Pp 17839-17847 (2014)
- Publication Year :
- 2014
-
Abstract
- A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey’s method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.
- Subjects :
- Indoles
Magnetic Resonance Spectroscopy
Eurotium cristatum
Stereochemistry
DPPH
Radical
Pharmaceutical Science
Diketopiperazines
radical scavenging activity
Mass Spectrometry
Article
Analytical Chemistry
Neoechinulin A
Cell Line
lcsh:QD241-441
chemistry.chemical_compound
Mice
Alkaloids
lcsh:Organic chemistry
Prenylation
Eurotium
Drug Discovery
Organic chemistry
Animals
Physical and Theoretical Chemistry
Indole test
Chemistry
Alkaloid
Organic Chemistry
Absolute configuration
diketopiperazine
Nuclear magnetic resonance spectroscopy
3T3 Cells
Free Radical Scavengers
Chemistry (miscellaneous)
Molecular Medicine
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 19
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....f9c2e678ec0fed245521a00e8a9d7ab7