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Adult-born neurons promote cognitive flexibility by improving memory precision and indexing
- Source :
- Hippocampus 31(10), 1068-1079 (2021). doi:10.1002/hipo.23373
- Publication Year :
- 2021
-
Abstract
- Adult neurogenesis in the hippocampal dentate gyrus (DG) is an extraordinary form of plasticity fundamental for cognitive flexibility. Recent evidence showed that newborn neurons differentially modulate input to the infra- and supra-pyramidal blades of the DG during the processing of spatial and contextual information, respectively. However, how this differential regulation by neurogenesis is translated into different aspects contributing cognitive flexibility is unclear. Here, we increased adult-born neurons by a genetic expansion of neural stem cells and studied their influence during navigational learning. We found that increased neurogenesis improved both memory precision and flexibility. Interestingly, each of these gains was associated with distinct subregional patterns of activity and better separation of memory representations in the DG-CA3 network. Our results highlight the role of adult-born neurons in promoting memory precision and indexing and suggests their anatomical allocation within specific DG-CA3 compartments, together contributing to cognitive flexibility.
- Subjects :
- Cognitive Neuroscience
Neurogenesis
Hippocampus
Biology
Hippocampal formation
cognitive flexibility
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Cognition
Neural Stem Cells
physiology [Dentate Gyrus]
0501 psychology and cognitive sciences
ddc:610
Neurons
Dentate gyrus
05 social sciences
Search engine indexing
physiology [Cognition]
Cognitive flexibility
Flexibility (personality)
physiology [Neurogenesis]
physiology [Neurons]
hippocampal neurogenesis
Neural stem cell
nervous system
memory precision
Dentate Gyrus
Neuroscience
030217 neurology & neurosurgery
indexing
Subjects
Details
- ISSN :
- 10981063
- Volume :
- 31
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- HippocampusREFERENCES
- Accession number :
- edsair.doi.dedup.....f9c327f34fb141ff4112c7f0d77d2b58