Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers

Highlights • HOTAIR and MALAT1 were upregulated in PBLCs of PAHs-exposed workers. • HOTAIR and MALAT1 expression was positively associated with the degree of DNA damage induced by PAHs. • H3K27me3 modification was positively correlated with the degree of genetic damage and the increase of HOTAIR expression.
To explore whether the alteration of lncRNA expression is correlated with polycyclic aromatic hydrocarbons (PAHs) exposure and DNA damage, we examined PAHs external and internal exposure, DNA damage and lncRNAs (HOTAIR, MALAT1, TUG1 and GAS5) expression in peripheral blood lymphocytes (PBLCs) of 150 male coke oven workers and 60 non-PAHs exposure workers. We found the expression of HOTAIR, MALAT1, and TUG1 were enhanced in PBLCs of coke oven workers and positively correlated with the levels of external PAHs exposure (adjusted Ptrend