Back to Search
Start Over
Hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation in adult patients with idiopathic aplastic anemia
- Source :
- Leukemia research. 37(10)
- Publication Year :
- 2013
-
Abstract
- We retrospectively investigated the incidence, risk factors, and outcomes of SOS (sinusoidal obstruction syndrome; previously veno-occlusive disease [VOD]) after allogeneic hematopoietic stem cell transplantation (alloHSCT) in aplastic anemia. Two hundred and sixty patients were included in the analysis. SOS developed in 7.3% (n=19/260) of patients. Classical Cy (200 mg/m(2))-ATG was the most common conditioning regimen (84.2%) in the SOS group. The SOS mortality rate was 4/19 (21.1%). Univariate analyses revealed that Cy 200 mg/m(2) conditioning (p=0.035), classical Cy-ATG conditioning (p=0.007), and horse ATG conditioning (p0.001) were significant risk factors for developing SOS. Multivariate analysis revealed that only horse ATG conditioning was a poor prognostic factor (HR=3.484; 95% CI 1.226-9.904; p=0.002). Rabbit ATG (HR 12.719; 95% CI 2.332-69.373; p=0.003) and weight gain10% (HR 35.655; 95% CI 2.208-575.805; p=0.012) were risk factors in the overall SOS group. Both rabbit ATG conditioning and weight gain of more than 10% were associated with poor overall survival with a median of 1.2 months (5Y survival rate, any risk factor vs. none: 74.6% vs. 0.0%; p0.001; Fig. 2) in the SOS group. In conclusion, SOS is a relatively rare (7.3%) but highly fatal (21.1%) acute complication of alloHSCT in AA, and the horse ATG conditioning regimen was a significant risk factor for developing SOS.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Transplantation Conditioning
Adolescent
medicine.medical_treatment
Hepatic Veno-Occlusive Disease
Hematopoietic stem cell transplantation
Gastroenterology
Young Adult
Risk Factors
Internal medicine
medicine
Humans
Transplantation, Homologous
Aplastic anemia
Risk factor
Survival rate
Retrospective Studies
Univariate analysis
business.industry
Incidence (epidemiology)
Mortality rate
Hematopoietic Stem Cell Transplantation
Horse
Anemia, Aplastic
Hematology
Middle Aged
medicine.disease
Prognosis
Surgery
Oncology
Female
business
Subjects
Details
- ISSN :
- 18735835
- Volume :
- 37
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Leukemia research
- Accession number :
- edsair.doi.dedup.....f9dde03d135c4150299d2e86db65fe96