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Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis
- Source :
- Autoimmune Diseases, Vol 2014 (2014), Autoimmune Diseases
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS). Bothex vivoanalyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+and CD4+T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss thepro et contraof possible therapies for MS targeting proteasome isoforms.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Cell type
biology
business.industry
Multiple sclerosis
Immunology
immunoproteasome, inflammation, multiple sclerosis
Review Article
Protein degradation
Pharmacology
medicine.disease
Cell biology
Immune system
Immunology and Microbiology (miscellaneous)
Proteasome
medicine
biology.protein
Immunology and Allergy
Antibody
business
lcsh:RC581-607
Intracellular
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 20900430 and 20900422
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Autoimmune Diseases
- Accession number :
- edsair.doi.dedup.....f9df4b5e24e117a6c1ab0e4c3ee7533b