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Alcohol consumption, but not smoking is associated with higher MR-derived liver fat in an asymptomatic study population
- Source :
- PLoS ONE 13:e0192448 (2018), PLoS ONE, Vol 13, Iss 2, p e0192448 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library Science, 2018.
-
Abstract
- Background The aim of our study was to determine the relation of alcohol consumption and cigarette smoking on continuous-measured hepatic fat fraction (HFF) in a population free of cardiovascular disease. We suggested a direct correlation of alcohol consumption with HFF and increased HFF in former smokers compared to current smokers. Methods Data from 384 subjects (mean age: 56 years, 58% men) of a population-based cohort study (KORA) were included in a cross-sectional design. Liver fat was assessed by 3 Tesla magnetic resonance imaging (MRI) using a multi-echo Dixon sequence and T2-corrected single voxel multi-echo spectroscopy (H-1-MRS). Smoking status was classified as never, former or current smoker and alcohol consumption as non-, moderate (0.1-39.9 g/day for men and 0.1-19.9 g/day for women), or heavy drinker (>= 40 g/day for men and >= 20 g/day for women). Fatty liver disease was defined as HFF >= 5.56%. Results Average HFF was 8.8% by H-1-MRS and 8.5% by MRI. Former smokers showed a higher HFF (MRI: beta = 2.64; p = 0.006) and a higher FLD prevalence (MRI: OR = 1.91; p = 0.006) compared to never smokers. Current smokers showed decreased odds for FLD measured by H-1-MRS after multivariable adjustment (OR = 0.37; p = 0.007) with never smoker as reference. Heavy drinking was positively associated with HFF (H-1-MRS: beta = 2.99; p = 0.003) and showed highest odds for FLD (H-1-MRS: OR = 3.05; p = 0.008) with non-drinker as reference. Moderate drinking showed a positive association with HFF (H-1-MRS: beta = 1.54; p = 0.061 and MRI: beta = 1.75; p = 0.050). Conclusions Our data revealed lowest odds for FLD in current smokers, moderate drinkers showing higher HFF than non-drinkers and heavy drinkers showing highest HFF and odds for FLD. These findings partly conflict with former literature and underline the importance of further studies to investigate the complex effects on liver metabolism.
- Subjects :
- Male
Magnetic Resonance Spectroscopy
Cross-sectional study
Physiology
lcsh:Medicine
Gastroenterology
Biochemistry
Diagnostic Radiology
Body Mass Index
Fats
Cohort Studies
Habits
0302 clinical medicine
Endocrinology
Medicine and Health Sciences
Smoking Habits
030212 general & internal medicine
Young adult
lcsh:Science
education.field_of_study
Multidisciplinary
Alcohol Consumption
Radiology and Imaging
Liver Diseases
Fatty liver
Smoking
Middle Aged
Magnetic Resonance Imaging
Lipids
Physiological Parameters
Adipose Tissue
Liver
Population study
030211 gastroenterology & hepatology
Female
medicine.symptom
Cohort study
Research Article
Adult
medicine.medical_specialty
Alcohol Drinking
Imaging Techniques
Endocrine Disorders
Population
Gastroenterology and Hepatology
Research and Analysis Methods
Asymptomatic
03 medical and health sciences
Young Adult
Diagnostic Medicine
Internal medicine
medicine
Diabetes Mellitus
Humans
ddc:610
education
Nutrition
Behavior
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Former Smoker
medicine.disease
Diet
Fatty Liver
Cross-Sectional Studies
Metabolic Disorders
lcsh:Q
business
Subjects
Details
- Language :
- German
- Database :
- OpenAIRE
- Journal :
- PLoS ONE 13:e0192448 (2018), PLoS ONE, Vol 13, Iss 2, p e0192448 (2018), PLoS ONE
- Accession number :
- edsair.doi.dedup.....f9ef910761a89be248c6992f5ce932b9