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Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney
- Source :
- Journal of magnetic resonance imaging : JMRI. 20(5)
- Publication Year :
- 2004
-
Abstract
- PURPOSE: To describe the use of MRI and a cortical-compartment model to measure the glomerular filtration rate (GFR), and compare the results with those obtained with the Patlak-Rutland model. MATERIALS AND METHODS: Dynamic MRI of rabbit kidneys was performed during and after injection of gadoterate dimeglumine. The enhancement curves in the aorta and the kidney were analyzed with the cortical-compartment and Patlak-Rutland models to assess the GFR. RESULTS: A substantial correlation was observed between the GFR measured with MRI using the cortical-compartment model and the plasma clearance of 51Cr-EDTA (r=0.821, P=0.004). No significant correlation was observed between the 51Cr-EDTA clearance (r=0.628, P=0.052) and the GFR obtained with the Patlak-Rutland model in regions of interest (ROIs) encompassing the renal cortex and medulla. A Bland and Altman analysis showed that GFR(cortical) (compartment) agreed better with the 51Cr-EDTA clearance compared to GFR(Patlak) when ROIs were limited to the cortex. However, the GFR values obtained by MRI were lower than the plasma clearance of 51Cr-EDTA. CONCLUSION: MRI with a cortical-compartment model provides more accurate assessments of glomerular filtration than the Patlak-Rutland model.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Time Factors
Renal cortex
Hypovolemia
Renal function
Contrast Media
urologic and male genital diseases
Kidney
Meglumine
medicine.artery
Cortex (anatomy)
medicine
Image Processing, Computer-Assisted
Organometallic Compounds
Animals
Radiology, Nuclear Medicine and imaging
Compartment (pharmacokinetics)
Aorta
medicine.diagnostic_test
urogenital system
business.industry
Reproducibility of Results
Magnetic resonance imaging
Image Enhancement
Magnetic Resonance Imaging
medicine.anatomical_structure
Dynamic contrast-enhanced MRI
Models, Animal
Rabbits
business
Nuclear medicine
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 10531807
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Accession number :
- edsair.doi.dedup.....f9f404de46d15ccfd447745ea3e4e1f0