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Markers of Cholesterol Metabolism in the Brain Show Stronger Associations with Cerebrovascular Disease than Alzheimer's Disease
- Source :
- Journal of Alzheimer's Disease. 30:53-61
- Publication Year :
- 2012
- Publisher :
- IOS Press, 2012.
-
Abstract
- Cholesterol metabolism is believed to play a role in the development of Alzheimer's disease (AD). Oxysterol metabolites of cholesterol, 24S-hydroxycholesterol (24-OHC, a brain-derived oxysterol) and 27-hydroxycholesterol (27-OHC, a peripherally derived oxysterol) cross the blood brain barrier and have been associated with AD. We investigated whether oxysterols were associated with markers of cerebrovascular disease prior to the onset of cognitive impairment. Oxysterols were quantified in 105 participants (average age: 80 ± 4 years) from the Pittsburgh Cardiovascular Health Study Cognition Study who remained cognitively normal at blood draw in 2002, had MRI in 1992 and 1998, and annual cognitive assessment for incident AD and mild cognitive impairment made by consensus conference between 1998 and 2010. Higher plasma levels of 24-OHC were associated with age, gender, the presence of high grade white matter hyperintensities, and brain infarcts on prior MRI. Participants with higher plasma 24-OHC and a greater ratio of 24-OHC/27-OHC were also more likely to develop incident cognitive impairment over 8 years of follow-up. Higher levels of 24-OHC suggest increased cholesterol metabolism occurring in the brains of participants with cerebrovascular disease prior to the onset of cognitive impairment. Measurement of oxysterols may provide information about cholesterol metabolism and brain disease over the cognitive impairment process.
- Subjects :
- Male
Oxysterol
Apolipoprotein E4
Physiology
Disease
Blood–brain barrier
Article
Cohort Studies
chemistry.chemical_compound
Alzheimer Disease
polycyclic compounds
medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
medicine.diagnostic_test
Cholesterol
General Neuroscience
Age Factors
Brain
Magnetic resonance imaging
Cognition
General Medicine
medicine.disease
Magnetic Resonance Imaging
Hydroxycholesterols
Hyperintensity
Cerebrovascular Disorders
Psychiatry and Mental health
Clinical Psychology
medicine.anatomical_structure
chemistry
Female
lipids (amino acids, peptides, and proteins)
sense organs
Geriatrics and Gerontology
Alzheimer's disease
Cognition Disorders
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....fa0ab78ffeeb1ef2851ce9d43415a2eb
- Full Text :
- https://doi.org/10.3233/jad-2012-111460