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Paraprotein–Related Kidney Disease: Kidney Injury from Paraproteins—What Determines the Site of Injury?
- Source :
- Clinical Journal of the American Society of Nephrology. 11:2288-2294
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Disorders of plasma and B cells leading to paraproteinemias are associated with a variety of renal diseases. Understanding the mechanisms of injury and associated nephropathies provides a framework that aids clinicians in prompt diagnosis and appropriate adjunctive treatment of these disorders. Glomerular diseases that may be associated with paraproteinemias include amyloid deposition, monoclonal Ig deposition disease, proliferative GN with monoclonal Ig deposits, C3 glomerulopathy caused by alterations in the complement pathway, immunotactoid glomerulopathy, fibrillary GN, and cryoglobulinemia. Tubular lesions include the classic Fanconi syndrome, light–chain proximal tubulopathy, interstitial fibrosis, and cast nephropathy. These paraproteinemic renal diseases are distinct in their pathogenesis as well as their urinary and kidney biopsy findings. Renal pathology is usually initiated by deposition and direct involvement of the intact monoclonal Ig or Ig fragments with resident cells of the nephron. Our review summarizes current insights into the underlying molecular pathogenesis of these interesting kidney lesions.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Epidemiology
Kidney Glomerulus
Paraproteinemias
030232 urology & nephrology
Critical Care and Intensive Care Medicine
Nephropathy
Kidney Tubules, Proximal
03 medical and health sciences
Glomerulonephritis
0302 clinical medicine
Glomerulopathy
medicine
Humans
Kidney Tubules, Distal
Transplantation
Kidney
business.industry
Fanconi syndrome
Amyloidosis
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Renal pathology
Nephrology
Immunology
Adjunctive treatment
Immunoglobulin Light Chains
Kidney Diseases
Immunoglobulin Heavy Chains
business
Moving Points in Nephrology
Paraproteins
Kidney disease
Subjects
Details
- ISSN :
- 1555905X and 15559041
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical Journal of the American Society of Nephrology
- Accession number :
- edsair.doi.dedup.....fa16fed7996104739d0429666bed700e