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Propagation of Error in Ocular Pharmacokinetic Parameters Estimate of Azithromycin in Rabbits
Propagation of Error in Ocular Pharmacokinetic Parameters Estimate of Azithromycin in Rabbits
- Source :
- Journal of Pharmaceutical Sciences. 102:2371-2379
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The ocular pharmacokinetic (PK) of azithromycin in rabbit eye tissues was evaluated following single-dose and multiple-dose administrations of azithromycin. Because of destructive sampling, only the average ocular tissue concentration–time curve could be captured and used to estimate the PK parameters failing to obtain their standard deviations. In the present study, formulas were explained in details to estimate the major PK parameter errors in destructive sampling. The PK parameters were obtained by analyzing average ocular tissue concentration–time curve and their standard deviations were calculated using the formula proposed in this paper. A case study was included to elucidate the potential application of the formulas. F-test for equality of variances and independent-samples t-test were carried out between test formulation and reference formulation in PK parameters. Thus, a new and simple method was proposed to compare PK behavior for these studies using destructive sampling, which can be potentially applied into other cases in the future. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2371–2379, 2013
- Subjects :
- Male
Propagation of uncertainty
Chemistry
Pharmaceutical Science
Destructive sampling
PK Parameters
Azithromycin
Bioequivalence
Pharmacology
Eye
Standard deviation
Anti-Bacterial Agents
Ocular tissue
Pharmacokinetics
Area Under Curve
medicine
Animals
Applied mathematics
Rabbits
Algorithms
Chromatography, High Pressure Liquid
medicine.drug
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....fa1bf27d79f5b316248ca55e9f9e48ed
- Full Text :
- https://doi.org/10.1002/jps.23557