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Endoscopic gastric mucosal atrophy distinguishes the characteristics of superficial esophagogastric junction adenocarcinoma
- Source :
- Digestive Endoscopy. 29:26-36
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Background and Aim Western studies have suggested two distinct etiologies of esophagogastric junction (EGJ) cancer: Helicobacter pylori-associated atrophic gastritis and non-atrophic gastric mucosa resembling esophageal adenocarcinoma. The present study investigated whether endoscopic gastric mucosal atrophy can distinguish between these two types of EGJ adenocarcinoma. Methods Data were collected from patients with Siewert type II, T1 EGJ adenocarcinoma who underwent endoscopic or surgical resection at eight Japanese institutions in 2010–2015. Clinicopathological characteristics of EGJ cancers with and without endoscopic gastric mucosal atrophy were compared. EGJ was defined as the lower end of the palisade vein and/or the top of the gastric folds. Results Of the 229 patients identified, 161 had endoscopic gastric mucosal atrophy and 68 did not. The latter group was younger (64 vs 70 years, P = 0.000); had a higher proportion of patients negative for H. pylori (90% vs 47%, P
- Subjects :
- Male
medicine.medical_specialty
Esophageal Neoplasms
Atrophic gastritis
Adenocarcinoma
Gastroenterology
Endoscopy, Gastrointestinal
Helicobacter Infections
03 medical and health sciences
0302 clinical medicine
Japan
Internal medicine
medicine
Gastric mucosa
Humans
Radiology, Nuclear Medicine and imaging
Esophagus
Vein
Aged
Retrospective Studies
Helicobacter pylori
business.industry
Reflux
Cancer
Odds ratio
Middle Aged
medicine.disease
medicine.anatomical_structure
Gastric Mucosa
Gastritis
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Esophagogastric Junction
Atrophy
business
Subjects
Details
- ISSN :
- 09155635
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Digestive Endoscopy
- Accession number :
- edsair.doi.dedup.....fa2dc3185899e91b88a30aeb09c15d10