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Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2019
-
Abstract
- Interstitial photodynamic therapy (iPDT) with 5-aminolevulinic acid (ALA) is a possible alternative treatment for malignant brain tumors. Further evaluation is, however, required before it can be clinically applied. Computational simulation of the photophysical process in ALA-iPDT can offer a quantitative tool for understanding treatment outcomes, which depend on various variables related to clinical treatment conditions. We propose a clinical simulation method of ALA-iPDT for malignant brain tumors using a singlet oxygen (O12) model and O12 threshold to induce cell death. In this method, the amount of O12 generated is calculated using a photosensitizer photobleaching coefficient and O12 quantum yield, which have been measured in several previous studies. Results of the simulation using clinical magnetic resonance imaging data show the need to specify the insertion positions of cylindrical light diffusers and the level of light fluence. Detailed analysis with a numerical brain tumor model demonstrates that ALA-iPDT treatment outcomes depend on combinations of photobleaching and threshold values. These results indicate that individual medical procedures, including pretreatment planning and treatment monitoring, will greatly benefit from simulation of ALA-iPDT outcomes.
- Subjects :
- Paper
medicine.medical_treatment
Malignant brain tumor
Biomedical Engineering
Brain tumor
Photodynamic therapy
01 natural sciences
Models, Biological
010309 optics
Biomaterials
chemistry.chemical_compound
0103 physical sciences
medicine
Humans
protoporphyrin IX
Photosensitizer
Computer Simulation
Special Section on Photodynamic Therapy
Photobleaching
Photosensitizing Agents
medicine.diagnostic_test
Protoporphyrin IX
Singlet Oxygen
Chemistry
Singlet oxygen
Brain Neoplasms
singlet oxygen model
Magnetic resonance imaging
Aminolevulinic Acid
medicine.disease
Magnetic Resonance Imaging
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Spectrometry, Fluorescence
Treatment Outcome
Photochemotherapy
photodynamic therapy
5-aminolevulinic acid
Biomedical engineering
Subjects
Details
- ISSN :
- 15602281
- Volume :
- 25
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of biomedical optics
- Accession number :
- edsair.doi.dedup.....fa5777693cfb904e0722d44b40023074