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Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones
- Source :
- Journal of the American Chemical Society. 133:16432-16435
- Publication Year :
- 2011
- Publisher :
- American Chemical Society (ACS), 2011.
-
Abstract
- A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.
- Subjects :
- Molecular Structure
Hydrogen
Benzoxazinones
Asymmetric hydrogenation
chemistry.chemical_element
Noyori asymmetric hydrogenation
Esters
Stereoisomerism
General Chemistry
Biochemistry
Reductive amination
Ruthenium
Catalysis
Benzoxazines
chemistry.chemical_compound
Colloid and Surface Chemistry
chemistry
Biomimetic Materials
Organometallic Compounds
Organic chemistry
Hydrogenation
Phosphoric acid
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....fa5a60e2f162eb9e69f6f506282f2595