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Visible-Light-Promoted Thiyl Radical Generation from Sodium Sulfinates: A Radical–Radical Coupling to Thioesters
- Source :
- Organic Letters. 21:3774-3779
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- A convenient visible-light photoredox catalysis has been developed for the synthesis of thioesters from two readily available starting materials: acid chlorides and sodium sulfinates. The facile generation of acyl radical species under the visible light photoredox conditions allows the formation of thiyl radical species from sodium sulfinates via multiple single electron transfer reactions, where the final acyl radical-thiyl radical coupling has been accomplished. The direct radical-radical coupling strategy offers a mild and controlled photochemical approach to important synthetic building blocks such as thioesters.
- Subjects :
- 010405 organic chemistry
Sodium
Organic Chemistry
Photoredox catalysis
chemistry.chemical_element
010402 general chemistry
Photochemistry
01 natural sciences
Biochemistry
0104 chemical sciences
Coupling (electronics)
Single electron
chemistry
lipids (amino acids, peptides, and proteins)
Physical and Theoretical Chemistry
Visible spectrum
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....fa75d3282bbbe0aa246155c5bf0d4c04