Back to Search
Start Over
Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis
- Source :
- Journal of neuroimmunology. 113(1)
- Publication Year :
- 2001
-
Abstract
- A complete prevention of clinical experimental autoimmune myasthenia gravis (EAMG) was observed in lymphotoxin (LT)-alpha deficient (LT-alpha(-/-)) mice compared to LT-alpha(+/+) mice when immunized with acetylcholine receptor. However, only a partial prevention of clinical EAMG incidence was observed in LT-beta(-/-) mice compared to LT-beta(+/+) mice. LT-alpha(-/-)and LT-beta(-/-) mice had lower mean titers of total IgG, IgG(1), IgG(2a) and IgG(2b) and higher or equal mean titers of IgM anti-AChR antibodies compared to controls. Therefore, LT-alpha(-/-)and LT-beta(-/-) AChR immunized mice are capable of mounting a primary (IgM) humoral immune response to AChR, but are less capable of switching to the pathogenic anti-AChR IgG isotypes. LT could play a significant role in the pathogenesis of myasthenia gravis.
- Subjects :
- Lymphotoxin alpha
C57BL/6
Immunology
Gene Expression
medicine.disease_cause
Receptors, Tumor Necrosis Factor
Autoimmunity
Mice
Immune system
Antigens, CD
medicine
Immunology and Allergy
Animals
Receptors, Cholinergic
Lymphotoxin-alpha
Acetylcholine receptor
Autoantibodies
Mice, Knockout
Membrane Glycoproteins
biology
Chemistry
Immunodominant Epitopes
medicine.disease
biology.organism_classification
Myasthenia gravis
Myasthenia Gravis, Autoimmune, Experimental
Mice, Inbred C57BL
Lymphotoxin
Neurology
Immunoglobulin M
Immunoglobulin G
biology.protein
Neurology (clinical)
B7-2 Antigen
Antibody
Spleen
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 113
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....fa7c33bcb45c8aa89c04059d0c604d6c