Bioorthogonal micellar nanoreactors for prodrug cancer therapy using an inverse-electron-demand Diels-Alder reaction

Authors :: Fumi Suehiro
Shota Fujii
Tomoki Nishimura
Source :: Chemical communications (Cambridge, England). 58(50)
Publication Year :: 2022
Abstract: Micellar nanoreactors based on the self-assembly of an IEDDA reactive unit bearing amphiphilic polymers are reported. The deployment of the nanoreactors for cancer chemotherapy via prodrug activation by the IEDDA reaction is also demonstrated.

Subjects :: Cycloaddition Reaction
Metals and Alloys
Electrons
General Chemistry
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Mice
Heterocyclic Compounds
Neoplasms
Materials Chemistry
Ceramics and Composites
Animals
Nanotechnology
Prodrugs
Micelles

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