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Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study
- Source :
- Frontiers in Neurology, Vol 12 (2021), Frontiers in Neurology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Introduction: Up to 27% of individuals undergoing subthalamic nucleus deep brain stimulation (STN-DBS) have a genetic form of Parkinson's disease (PD). Glucocerebrosidase (GBA) mutation carriers, compared to sporadic PD, present with a more aggressive disease, less asymmetry, and fare worse on cognitive outcomes with STN-DBS. Evaluating STN intra-operative local field potentials provide the opportunity to assess and compare symmetry between GBA and non-GBA mutation carriers with PD; thus, providing insight into genotype and STN physiology, and eligibility for and programming of STN-DBS. The purpose of this pilot study was to test differences in left and right STN resting state beta power in non-GBA and GBA mutation carriers with PD.Materials and Methods: STN (left and right) resting state local field potentials were recorded intraoperatively from 4 GBA and 5 non-GBA patients with PD while off medication. Peak beta power expressed as a ratio to total beta power (peak beta ratio) was compared between STN hemispheres and groups while co-varying for age, age of disease onset, and disease severity.Results: Peak beta ratio was significantly different between the left and the right STN for the GBA group (p < 0.01) but not the non-GBA group (p = 0.56) after co-varying for age, age of disease onset, and disease severity.Discussion: Peak beta ratio in GBA mutation carriers was more asymmetric compared with non-mutation carriers and this corresponded with the degree of clinical asymmetry as measured by rating scales. This finding suggests that GBA mutation carriers have a physiologic signature that is distinct from that found in sporadic PD.
- Subjects :
- medicine.medical_specialty
Parkinson's disease
Deep brain stimulation
medicine.medical_treatment
Aggressive disease
Disease
Internal medicine
subthalamic nucleus beta power
Medicine
RC346-429
Beta (finance)
Original Research
GBA mutation carriers
Resting state fMRI
business.industry
medicine.disease
nervous system diseases
deep brain stimulation
local field potential (LFP)
surgical procedures, operative
nervous system
Neurology
Mutation (genetic algorithm)
Cardiology
Neurology. Diseases of the nervous system
Neurology (clinical)
business
therapeutics
Glucocerebrosidase
Subjects
Details
- ISSN :
- 16642295
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neurology
- Accession number :
- edsair.doi.dedup.....fa8a81c2943d0f0bf928dbf4c5d07cf6
- Full Text :
- https://doi.org/10.3389/fneur.2021.723476