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Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication
- Source :
- Open Forum Infectious Diseases
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR+/CD38+ activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2–specific antibody responses were absent and SARS-CoV-2–specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.<br />We describe defects in severe acute respiratory syndrome coronavirus 2–specific immune responses and persistent viral replication in a patient with lymphoma. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.
- Subjects :
- Cellular immunity
viruses
lymphoma
cellular immunity
CD38
medicine.disease_cause
Immune system
humoral immunity
Medicine
Interleukin 6
Coronavirus
biology
SARS-CoV-2
business.industry
Brief Report
COVID-19
virus diseases
Editor's Choice
AcademicSubjects/MED00290
Infectious Diseases
Oncology
Viral replication
Humoral immunity
Immunology
biology.protein
Interleukin 18
immunocompromise
business
Subjects
Details
- ISSN :
- 23288957
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases
- Accession number :
- edsair.doi.dedup.....fa8e830d7679a09d0da27e134fbea13a