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The Contribution of Risk Factors to the Higher Incidence of Invasive and In Situ Breast Cancers in Women With Higher Levels of Education in the European Prospective Investigation Into Cancer and Nutrition
- Source :
- American Journal of Epidemiology; Vol 173, American journal of epidemiology, 173(1), 26-37. Oxford University Press, American Journal of Epidemiology, American Journal of Epidemiology, Oxford University Press (OUP), 2011, 173 (1), pp.26-37. ⟨10.1093/aje/kwq319⟩, Menvielle, G, Kunst, A E, van Gils, C H, Peeters, P H, Boshuizen, H, Overvad, K, Olsen, A, Tjonneland, A, Hermann, S, Kaaks, R, Bergmann, M M, Illner, A-K, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Palli, D, Berrino, F, Mattiello, A, Tumino, R, Sacerdote, C, May, A, Monninkhof, E, Braaten, T, Lund, E, Quirós, J R, Duell, E J, Sánchez, M-J, Navarro, C, Ardanaz, E, Borgquist, S, Manjer, J, Khaw, K T, Allen, N E, Reeves, G K, Chajes, V, Rinaldi, S, Slimani, N, Gallo, V, Vineis, P, Riboli, E & Bueno-de-Mesquita, H B 2011, ' The contribution of risk factors to the higher incidence of invasive and in situ breast cancers in women with higher levels of education in the European prospective investigation into cancer and nutrition ', American Journal of Epidemiology, vol. 173, no. 1, pp. 26-37 . https://doi.org/10.1093/aje/kwq319, American Journal of Epidemiology, 2011, 173 (1), pp.26-37. ⟨10.1093/aje/kwq319⟩, American Journal of Epidemiology, 173(1), 26-37. Oxford University Press
- Publication Year :
- 2011
- Publisher :
- OXFORD UNIV PRESS INC, 2011.
-
Abstract
- International audience; The authors investigated the role of known risk factors in educational differences in breast cancer incidence. Analyses were based on the European Prospective Investigation Into Cancer and Nutrition and included 242,095 women, 433 cases of in situ breast cancer, and 4,469 cases of invasive breast cancer. Reproductive history (age at first full-term pregnancy and parity), exposure to endogenous and exogenous hormones, height, and health behaviors were accounted for in the analyses. Relative indices of inequality (RII) for education were estimated using Cox regression models. A higher risk of invasive breast cancer was found among women with higher levels of education (RII = 1.22, 95% confidence interval (CI): 1.09, 1.37). This association was not observed among nulliparous women (RII = 1.13, 95% CI: 0.84, 1.52). Inequalities in breast cancer incidence decreased substantially after adjusting for reproductive history (RII = 1.11, 95% CI: 0.98, 1.25), with most of the association being explained by age at first full-term pregnancy. Each other risk factor explained a small additional part of the inequalities in breast cancer incidence. Height accounted for most of the remaining differences in incidence. After adjusting for all known risk factors, the authors found no association between education level and risk of invasive breast cancer. Inequalities in incidence were more pronounced for in situ breast cancer, and those inequalities remained after adjustment for all known risk factors (RII = 1.61, 95% CI: 1.07, 2.41), especially among nulliparous women.
- Subjects :
- MESH: Reproductive History
Epidemiology
MESH: Risk Assessment
0302 clinical medicine
MESH: Risk Factors
Prevalence
breast neoplasms
Mass Screening
risk factors
Prospective Studies
030212 general & internal medicine
MESH: Incidence
Prospective cohort study
reproductive history
MESH: Aged
education
MESH: Middle Aged
Obstetrics
Incidence (epidemiology)
MESH: Follow-Up Studies
Middle Aged
Nutrition Surveys
Prognosis
3. Good health
European Prospective Investigation into Cancer and Nutrition
Europe
030220 oncology & carcinogenesis
Educational Status
Female
Breast disease
Risk assessment
Adult
medicine.medical_specialty
Risk Assessment
Article
MESH: Prognosis
03 medical and health sciences
Breast cancer
SDG 3 - Good Health and Well-being
MESH: Nutrition Surveys
medicine
Humans
Neoplasm Invasiveness
MESH: Mass Screening
Risk factor
MESH: Prevalence
Aged
Gynecology
MESH: Humans
business.industry
Cancer
MESH: Adult
MESH: Neoplasm Invasiveness
medicine.disease
MESH: Prospective Studies
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
incidence
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Europe
business
MESH: Educational Status
MESH: Female
MESH: Breast Neoplasms
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14766256 and 00029262
- Volume :
- 173
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- American Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....fab19b3d8b081fef64082b9a42206ae6
- Full Text :
- https://doi.org/10.1093/aje/kwq319