Back to Search
Start Over
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis
- Source :
- BMJ. 4:470-473
- Publication Year :
- 1969
- Publisher :
- BMJ, 1969.
-
Abstract
- Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.
- Subjects :
- Male
Drug
Trimethoprim-sulphamethoxazole
medicine.medical_specialty
Chronic bronchitis
Sulfamethoxazole
media_common.quotation_subject
Ampicillin
Internal medicine
medicine
Humans
Bronchitis
General Environmental Science
media_common
Clinical Trials as Topic
business.industry
Sputum
General Engineering
Drug Synergism
Papers and Originals
General Medicine
medicine.disease
Trimethoprim
Blood Cell Count
Surgery
Pyrimidines
Chronic Disease
Folic Acid Antagonists
General Earth and Planetary Sciences
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 14685833 and 09598138
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....fad871979db42025d9f4b3f6409426af