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Applying Genomic Epidemiology to Characterize a COVID-19 Outbreak in a Developmentally Disabled Adult Group Home Setting, Arizona
- Source :
- Frontiers in Public Health, Frontiers in Public Health, Vol 9 (2021)
- Publication Year :
- 2021
-
Abstract
- Individuals living in congregate settings, including those in group homes, have been disproportionately impacted by COVID-19 and may be at increased risk of exposure or infection due to underlying illness. In mid-May 2020, local public health officials responded to an outbreak of COVID-19 among staff and residents associated with a multi-residential group home that provides care for adults with intellectual and developmental disabilities. Samples were collected at 16 of the homes. In four of the homes all the residents tested positive, and in the remaining 12 houses where samples were collected, all residents tested negative. Of the 152 individuals tested, 15/58 (25.9%) residents and 27/94 (28.7%) staff were positive for SARS-CoV-2, including eight hospitalizations and four deaths. Phylogenetic analysis of genomes from this outbreak in the context of genomes from Northern Arizona shows that very few mutations separate the samples from this outbreak. A potential transmission network was developed to illustrate person-place epidemiologic linkages and further demonstrates the dynamic connections between staff and residents with respect to each group home location. Epidemiologic and genomic evidence correlate, and suggest that asymptomatic infected staff likely introduced and spread COVID-19 in this setting. Implementation of public health prevention measures alongside rapid genomic analysis can help guide policy development and guide management efforts to prevent and mitigate future outbreaks.
- Subjects :
- Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Group home
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Group Homes
Context (language use)
genomic epidemiology
Disease Outbreaks
03 medical and health sciences
0302 clinical medicine
Environmental health
Epidemiology
Medicine
Humans
Phylogeny
030304 developmental biology
0303 health sciences
outbreak
business.industry
SARS-CoV-2
Public health
Public Health, Environmental and Occupational Health
Arizona
Outbreak
COVID-19
Genomics
developmental disabilities
Brief Research Report
Nursing Homes
Increased risk
Public Health
Public aspects of medicine
RA1-1270
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22962565
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in public health
- Accession number :
- edsair.doi.dedup.....fadb7bbc1a50292bd86a8791954c5f2b