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Cryotherapy in extra-abdominal desmoid tumors: A systematic review and meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 12, p e0261657 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Introduction Desmoid tumor is a locally-invasive neoplasm that causes significant morbidity. There is recent interest in cryotherapy for treatment of extra-abdominal desmoid tumors. This systematic review assesses evidence on safety and efficacy of cryotherapy in the treatment of extra-abdominal desmoid tumors. Materials and methods The systematic review was conducted with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Literature search was performed using MEDLINE and the Cochrane Central Register of Controlled Trials. 9 full text papers were reviewed and meta-analysis was performed for measures of safety, efficacy and symptom relief. Results The estimated pooled proportion of major and minor complications was 4.2% (95% CI, 1.8–9.6; I 2 = 0%) and 10.2% (95% CI, 5.7–17.8; I 2 = 0%) respectively. The estimated pooled proportion of non-progressive disease rate of all studies was 85.8% (95% CI, 73.4–93.0; I 2 = 32.9%). The estimated progression free survival rate at 1 year was 84.5% (95% CI:74.6–95.8) and 78.0% at 3 years (95% CI: 63.8–95.3). As for pain control, the estimated pooled proportion of patients with decrease in visual analogue scale (VAS) > = 3 for those with VAS > = 3 before treatment for 2 studies was 87.5% (95% CI, 0.06–100; I 2 = 71.5%) while 37.5% to 96.9% of patients were reported to have experienced partial or complete symptom relief in the other studies. Conclusion Cryotherapy is a safe and effective treatment modality for extra-abdominal desmoid tumors with efficacy similar to those treated with traditional strategies in the short to medium term.
- Subjects :
- Cryoablation
Clinical Oncology
Systematic Reviews
Imaging Techniques
Epidemiology
Science
Cancer Treatment
Pain
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Diagnostic Radiology
Signs and Symptoms
Diagnostic Medicine
Medicine and Health Sciences
Humans
Multidisciplinary
Radiology and Imaging
Cancer Risk Factors
Cancers and Neoplasms
Research Assessment
Magnetic Resonance Imaging
Progression-Free Survival
Fibromatosis, Aggressive
Surgical Oncology
Treatment Outcome
Oncology
Cryotherapy
Medical Risk Factors
Medicine
Clinical Medicine
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....faf8a05c621eb4000c0324d5d836a96f