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Serum placental protein 14 in pre-menopausal and post-menopausal women--dependency on oestrogen/progestogen status
- Source :
- Maturitas. 12(2)
- Publication Year :
- 1990
-
Abstract
- In view of the increasing use of oestrogen-progestogen therapy in post-menopausal women the availability of possible biochemical marker of endometrial response to progestogen would be highly desirable. Placental protein 14 (PP14) has recently been shown to be excreted from the endometrium during the secretory phase of the menstrual cycle. In the present study we examined the concentration of serum PP14 (S-PP14) in 15 pre-menopausal women during the menstrual cycle and in 30 early post-menopausal women receiving three different doses of 17 beta-oestradiol (E2), cyclically combined with norethisterone acetate (NETA). S-PP14 levels peaked on day 1 following the onset of menstrual bleeding and on day 7 during NETA administration. It was possible to estimate the area under the S-PP14 curve reliably from one or two blood samples taken at optimal times. In the post-menopausal women, S-PP14 varied in a highly significant dose-dependent manner, i.e., the higher the E2 dose (in relation to the fixed NETA dose) the higher the S-PP14 response was found to be. We suggest that S-PP14 measurements might reflect the quantitative development of the endometrium in the secretory phase in both pre-menopausal and post-menopausal women.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
media_common.quotation_subject
Pregnancy Proteins
Endometrium
General Biochemistry, Genetics and Molecular Biology
Pre menopausal
Internal medicine
Medicine
Humans
Menstrual cycle
Menstrual Cycle
Progesterone
media_common
Glycoproteins
Glycodelin
Progestogen
Estradiol
business.industry
Estriol
Estrogen Replacement Therapy
Obstetrics and Gynecology
Placental protein
Norethindrone Acetate
Middle Aged
Norethisterone acetate
medicine.anatomical_structure
Endocrinology
Female
Menopause
Norethindrone
business
medicine.drug
Subjects
Details
- ISSN :
- 03785122
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Maturitas
- Accession number :
- edsair.doi.dedup.....fb0e7bb2f7701324a63087ec2b7c4f58