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Evidence of coat color variation sheds new light on ancient canids
- Source :
- PLoS ONE, PLoS ONE, 2013, 8 (10), pp.e75110. ⟨10.1371/journal.pone.0075110⟩, PLoS ONE, Public Library of Science, 2013, 8 (10), pp.e75110. ⟨10.1371/journal.pone.0075110⟩, PLoS ONE, Vol 8, Iss 10, p e75110 (2013)
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; We have used a paleogenetics approach to investigate the genetic landscape of coat color variation in ancient Eurasian dog and wolf populations. We amplified DNA fragments of two genes controlling coat color, Mc1r (Melanocortin 1 Receptor) and CBD103 (canine-β-defensin), in respectively 15 and 19 ancient canids (dogs and wolf morphotypes) from 14 different archeological sites, throughout Asia and Europe spanning from ca. 12 000 B.P. (end of Upper Palaeolithic) to ca. 4000 B.P. (Bronze Age). We provide evidence of a new variant (R301C) of the Melanocortin 1 receptor (Mc1r) and highlight the presence of the beta-defensin melanistic mutation (CDB103-K locus) on ancient DNA from dog-and wolf-morphotype specimens. We show that the dominant K(B) allele (CBD103), which causes melanism, and R301C (Mc1r), the variant that may cause light hair color, are present as early as the beginning of the Holocene, over 10 000 years ago. These results underline the genetic diversity of prehistoric dogs. This diversity may have partly stemmed not only from the wolf gene pool captured by domestication but also from mutations very likely linked to the relaxation of natural selection pressure occurring in-line with this process.
- Subjects :
- 0106 biological sciences
Coat
Molecular Sequence Data
lcsh:Medicine
Zoology
Locus (genetics)
Biology
010603 evolutionary biology
01 natural sciences
DNA, Mitochondrial
03 medical and health sciences
Dogs
Animals
lcsh:Science
Domestication
Hair Color
Alleles
030304 developmental biology
0303 health sciences
Genetic diversity
Multidisciplinary
Wolves
Melanism
[SDV.BA]Life Sciences [q-bio]/Animal biology
lcsh:R
Paleogenetics
Ancient DNA
Mutation
lcsh:Q
Gene pool
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, 2013, 8 (10), pp.e75110. ⟨10.1371/journal.pone.0075110⟩, PLoS ONE, Public Library of Science, 2013, 8 (10), pp.e75110. ⟨10.1371/journal.pone.0075110⟩, PLoS ONE, Vol 8, Iss 10, p e75110 (2013)
- Accession number :
- edsair.doi.dedup.....fb1009477e0128fb80be2ab8c51ac66c