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Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial
Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial
- Source :
- Blood. 117:2614-2617
- Publication Year :
- 2011
- Publisher :
- American Society of Hematology, 2011.
-
Abstract
- We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by 99mTc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow cytometry. Loss of splenic function began before 12 months of age in 86% of infants in association with lower total or fetal hemoglobin and higher white blood cell or reticulocyte counts, reinforcing the need for early diagnosis and diligent preventive care. PIT and HJB correlated well with each other and liver-spleen scan results. Previously described biomarker threshold values did define patients with abnormal splenic function, but our data suggest that normal spleen function is better predicted by PIT of ≤ 1.2% or HJB ≤ 55/106 red blood cells and absent function by PIT ≥ 4.5% or HJB ≥ 665/106. HJB is methodologically advantageous compared with PIT, but both are valid biomarkers of splenic function. This trial was registered at www.clinicaltrials.gov as #NCT00006400.
- Subjects :
- Male
Hemolytic anemia
medicine.medical_specialty
Pathology
Clinical Trials and Observations
Anemia
Immunology
Spleen
Anemia, Sickle Cell
Biochemistry
Gastroenterology
White blood cell
Internal medicine
Fetal hemoglobin
medicine
Humans
Hematology
business.industry
Infant
Cell Biology
medicine.disease
Sickle cell anemia
Erythrocyte Inclusions
medicine.anatomical_structure
Hemoglobinopathy
Liver
Erythrocyte Count
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....fb14c472f3d8070bf4d31aa08c1c3e9b
- Full Text :
- https://doi.org/10.1182/blood-2010-04-278747