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Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial

Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial

Authors :
Scott T. Miller
Rathi V. Iyer
Russell E. Ware
Zora R. Rogers
Bea Files
Barry L. Shulkin
John H. Miller
Eglal Shalaby-Rana
Winfred C. Wang
Bruce W. Thompson
Zhaoyu Luo
Peter A. Lane
Stephen D. Dertinger
Source :
Blood. 117:2614-2617
Publication Year :
2011
Publisher :
American Society of Hematology, 2011.

Abstract

We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by 99mTc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow cytometry. Loss of splenic function began before 12 months of age in 86% of infants in association with lower total or fetal hemoglobin and higher white blood cell or reticulocyte counts, reinforcing the need for early diagnosis and diligent preventive care. PIT and HJB correlated well with each other and liver-spleen scan results. Previously described biomarker threshold values did define patients with abnormal splenic function, but our data suggest that normal spleen function is better predicted by PIT of ≤ 1.2% or HJB ≤ 55/106 red blood cells and absent function by PIT ≥ 4.5% or HJB ≥ 665/106. HJB is methodologically advantageous compared with PIT, but both are valid biomarkers of splenic function. This trial was registered at www.clinicaltrials.gov as #NCT00006400.

Details

ISSN :
15280020 and 00064971
Volume :
117
Database :
OpenAIRE
Journal :
Blood
Accession number :
edsair.doi.dedup.....fb14c472f3d8070bf4d31aa08c1c3e9b
Full Text :
https://doi.org/10.1182/blood-2010-04-278747