Cumulative risk assessment by environmental to EDC's mixture exposure, a still open problem

Background All people are exposed to endocrine disrupting chemicals (EDC's) as Bisphenol A (BPA) and phthalates every day. Phthalates and BPA are primarily excreted in the urine, therefore, only using the hydrolytic phthalate monoesters as the biomarkers of exposure in an epidemiological study could introduce exposure's misclassification because the other metabolites are not accounted for, hence, the most complete approach for their biomonitoring is a multi-residue …