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Differentiation between high-grade gliomas and solitary brain metastases: a comparison of five diffusion-weighted MRI models
- Source :
- BMC Medical Imaging
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background To compare the diagnostic performance of neurite orientation dispersion and density imaging (NODDI), mean apparent propagator magnetic resonance imaging (MAP-MRI), diffusion kurtosis imaging (DKI), diffusion tensor imaging (DTI) and diffusion-weighted imaging (DWI) in distinguishing high-grade gliomas (HGGs) from solitary brain metastases (SBMs). Methods Patients with previously untreated, histopathologically confirmed HGGs (n = 20) or SBMs (n = 21) appearing as a solitary and contrast-enhancing lesion on structural MRI were prospectively recruited to undergo diffusion-weighted MRI. DWI data were obtained using a q-space Cartesian grid sampling procedure and were processed to generate parametric maps by fitting the NODDI, MAP-MRI, DKI, DTI and DWI models. The diffusion metrics of the contrast-enhancing tumor and peritumoral edema were measured. Differences in the diffusion metrics were compared between HGGs and SBMs, followed by receiver operating characteristic (ROC) analysis and the Hanley and McNeill test to determine their diagnostic performances. Results NODDI-based isotropic volume fraction (Viso) and orientation dispersion index (ODI); MAP-MRI-based mean-squared displacement (MSD) and q-space inverse variance (QIV); DKI-generated radial, mean diffusivity and fractional anisotropy (RDk, MDk and FAk); and DTI-generated radial, mean diffusivity and fractional anisotropy (RD, MD and FA) of the contrast-enhancing tumor were significantly different between HGGs and SBMs (p iso, MSD, RDk and RD for NODDI, MAP-MRI, DKI and DTI, respectively. The AUC of Viso (0.871) was significantly higher than that of MSD (0.736), RDk (0.760) and RD (0.733) (p Conclusion NODDI outperforms MAP-MRI, DKI, DTI and DWI in differentiating between HGGs and SBMs. NODDI-based Viso has the highest performance.
- Subjects :
- Adult
Male
Contrast Media
Brain Edema
Neuroimaging
Sensitivity and Specificity
Young Adult
Magnetic resonance imaging
Glioma
Fractional anisotropy
Non-Gaussian
medicine
Peritumoral edema
Humans
Radiology, Nuclear Medicine and imaging
Diffusion Kurtosis Imaging
Aged
medicine.diagnostic_test
Receiver operating characteristic
Brain Neoplasms
business.industry
Brain metastasis
Middle Aged
medicine.disease
Diffusion Magnetic Resonance Imaging
ROC Curve
Female
Diffusion-weighted imaging
Nuclear medicine
business
Research Article
Diffusion MRI
Subjects
Details
- ISSN :
- 14712342
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Medical Imaging
- Accession number :
- edsair.doi.dedup.....fb46497e4cf7746e639a9e36ccba860b