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Effects of lobeline and reboxetine, fluoxetine, or bupropion combination on depression-like behaviors in mice

Authors :
Monzurul Amin Roni
Shafiqur Rahman
Source :
Pharmacology Biochemistry and Behavior. 139:1-6
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Evidence suggests that lobeline, a nicotinic acetylcholine receptor ligand, has antidepressant-like properties in mice. The present study investigated the possible additive or synergistic effects of lobeline in combination with commonly used antidepressants, such as reboxetine, fluoxetine, or bupropion, using the tail suspension test (TST) and the forced swim test (FST) in C57BL/6J mice. Reboxetine (5 or 10 mg/kg, i.p.), fluoxetine (5 or 10 mg/kg, i.p.), or bupropion (2 or 4 mg/kg, i.p.) were administered 30 min before TST or FST. A fixed dose of lobeline (1 mg/kg, i.p.) was injected 15 min prior to tests. Co-administration of lobeline and reboxetine, fluoxetine, or bupropion significantly reduced immobility time in the TST and FST in comparison to the antidepressants used alone. The results suggest that lobeline enhanced the effects of reboxetine, fluoxetine, or bupropion in mice. Therefore, lobeline or similar nicotinic receptor ligand may have therapeutic potential as an adjunct for the treatment of major depression.

Details

ISSN :
00913057
Volume :
139
Database :
OpenAIRE
Journal :
Pharmacology Biochemistry and Behavior
Accession number :
edsair.doi.dedup.....fb48d5ff609174b81d32b9eca94b7462
Full Text :
https://doi.org/10.1016/j.pbb.2015.10.006