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Early Biomarkers of Renal Damage in Relation to Arterial Stiffness and Inflammation in Male Coronary Artery Disease Patients
- Source :
- Kidney & Blood Pressure Research, Vol 41, Iss 4, Pp 488-497 (2016)
- Publication Year :
- 2016
-
Abstract
- Background/Aims: Plasma neutrophil gelatinase-associated lipocalin (NGAL), urinary liver-type fatty acid-binding protein (L-FABP) and urinary kidney injury molecule-1 (KIM-1) have emerged as promising biomarkers for both acute and chronic kidney injury that also provide prognostic value for cardiovascular morbidity and mortality. Our aim was to evaluate their relationships with arterial stiffness and inflammation in coronary artery disease (CAD) patients and in clinically healthy controls. Methods: We studied 52 patients with CAD (age 63.2 ± 9.2 years) and 41 healthy controls (age 60.1 ± 7.2 years). Urinary L-FABP and KIM-1 as well as serum NGAL, adiponectin and resistin levels were measured using the enzyme-linked immunosorbent assay method. The technique of applanation tonometry was used for non-invasive pulse wave analysis and pulse wave velocity assessments. Results: Urinary L-FABP and KIM-1 were independent determinants of cf-PWV for the CAD patients (R2=0.584, Pr=0.31, P=0.028) only for the patients, while NGAL correlated with WBC count (rho=0.29, P=0.038; r=0.35, P=0.029) and resistin (rho=0.60, PConclusion: Our findings suggest that urinary L-FABP and KIM-1 may be independently associated with aortic stiffness in individuals with CAD.
- Subjects :
- Male
lcsh:Diseases of the circulatory (Cardiovascular) system
030232 urology & nephrology
Coronary Artery Disease
030204 cardiovascular system & hematology
Lipocalin
lcsh:RC870-923
Gastroenterology
Coronary artery disease
L-FABP
0302 clinical medicine
lcsh:Dermatology
Hepatitis A Virus Cellular Receptor 1
Prospective Studies
NGAL
Pulse wave velocity
integumentary system
Renal damage
General Medicine
Middle Aged
Arterial stiffness
Novel kidney injury markers
Nephrology
Cardiology
lipids (amino acids, peptides, and proteins)
Kidney Diseases
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Urinary system
Inflammation
Fatty Acid-Binding Proteins
03 medical and health sciences
Vascular Stiffness
Internal medicine
medicine
Kidney injury
Humans
KIM-1
Aged
business.industry
lcsh:RL1-803
medicine.disease
Atherosclerosis
lcsh:Diseases of the genitourinary system. Urology
Early Diagnosis
lcsh:RC666-701
Case-Control Studies
business
Biomarkers
Subjects
Details
- ISSN :
- 14230143
- Volume :
- 41
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Kidneyblood pressure research
- Accession number :
- edsair.doi.dedup.....fb4e9e61d7bbcc1d0db64c9f42b0a4a0