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Gut Microbiota Metabolite Fights Against Dietary Polysorbate 80-Aggravated Radiation Enteritis
- Source :
- Frontiers in Microbiology, Vol 11 (2020), Frontiers in Microbiology
- Publication Year :
- 2020
- Publisher :
- Frontiers Media S.A., 2020.
-
Abstract
- Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S ribosomal RNA high-throughput sequencing analysis indicated that P80 consumption altered the abundance and composition of the gut microbiota, leading to severe radiation-induced GI tract injury. Mice harboring fecal microbes from P80-treated mice were highly susceptible to irradiation, and antibiotics-challenged mice also represented more sensitive to radiation following P80 treatment. Importantly, butyrate, a major metabolite of enteric microbial fermentation of dietary fibers, exhibited beneficial effects against P80 consumption-aggravated intestinal toxicity via the activation of G-protein-coupled receptors (GPCRs) and maintenance of the intestinal bacterial composition in irradiated animals. Moreover, butyrate had broad therapeutic effects on common radiation-induced injury. Collectively, our findings demonstrate that P80 are potential risk factors for cancer patients during radiotherapy and indicate that butyrate might be employed as a therapeutic option to mitigate the complications associated with radiotherapy.
- Subjects :
- Microbiology (medical)
intestinal microbiota
Metabolite
lcsh:QR1-502
Butyrate
Gut flora
Pharmacology
Microbiology
Radiation enteropathy
lcsh:Microbiology
03 medical and health sciences
chemistry.chemical_compound
medicine
Radiation Enteritis
emulsifier
Receptor
Original Research
030304 developmental biology
0303 health sciences
biology
GPR43
030306 microbiology
business.industry
Cancer
medicine.disease
biology.organism_classification
radiation enteropathy
chemistry
Toxicity
business
gut microbiota metabolite
Subjects
Details
- Language :
- English
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....fb51e3bd77180f7bd4d2d402a4058fe2