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Clinical characteristics and outcomes of non-cystic fibrosis patients with Burkholderia cepacia complex bacteremia at a medical center in Taiwan
- Source :
- Journal of Microbiology, Immunology and Infection. 55:1301-1309
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- BACKGROUND Burkholderia cepacia complex (BCC) represents a group of multidrug-resistant gram-negative bacteria that cause infections among immunocompromised hosts. Bacteremia occurs in patients who are chronically ill and is associated with substantial morbidity and mortality. The aim of this study was to investigate the clinical characteristics and outcomes of BCC bacteremic patients without cystic fibrosis. METHODS We conducted a retrospective study at the National Taiwan University Hospital. Adults with BCC bacteremia from January 2015 to May 2019 were enrolled. The primary outcome was 14-day mortality. Multivariable logistic regression was performed for outcome analysis. RESULTS One-hundred and ninety-five patients were analyzed and their mean age was 67 years. Over 95% of the BCC isolates were susceptible to trimethoprim/sulfomethoxazole (TMP/SXT). Levofloxacin resistance rates were high, with only 25.1% of isolates being susceptible. Pairwise comparisons were made between different definitive regimens including meropenem-monotherapy, ceftazidime-monotherapy, levofloxacin-monotherapy, TMP/SXT-monotherapy, tigecycline-monotherapy as well as combination versus monotherapy. No regimen was significantly associated with survival in our study. Multivariable logistic regression showed that the Pitt bacteremia score (adjust odds ratio [aOR],1.46; 95% confidence interval [CI],1.19-1.79; p
- Subjects :
- Adult
Microbiology (medical)
medicine.medical_specialty
Cystic Fibrosis
Taiwan
Bacteremia
Levofloxacin
Burkholderia cepacia
Logistic regression
Trimethoprim
Internal medicine
Humans
Immunology and Allergy
Medicine
Risk factor
Aged
Retrospective Studies
General Immunology and Microbiology
biology
business.industry
Burkholderia cepacia complex
Burkholderia Infections
Retrospective cohort study
General Medicine
Odds ratio
biology.organism_classification
medicine.disease
Fibrosis
Hospitals
Anti-Bacterial Agents
Regimen
Infectious Diseases
business
medicine.drug
Subjects
Details
- ISSN :
- 16841182
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of Microbiology, Immunology and Infection
- Accession number :
- edsair.doi.dedup.....fb64bc2f60a8e8e74da6546c501fc52a