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A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 9, p e45849 (2012)
- Publication Year :
- 2012
-
Abstract
- Background Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common e2/e3/e4 polymorphism in Apo E gene on the risk of gallbladder stone disease. Method Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. Results There were 17 study populations totaling 1773 cases and 2751 controls for e2/e3/e4 polymorphism of Apo E gene. Overall comparison of alleles e2 with e3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68–1.05; P = 0.31; I2 = 13%), and comparison of alleles e4 with e3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97–1.61; P = 0.0003; I2 = 63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for e4 allelic model (odds ratio [OR] = 1.46; 95% CI: 1.05–2.02; p = 0.0007; I2 = 65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in e4 allelic model (OR = 1.50; 95% CI: 1.03–2.19; p = 0.0009; I2 = 72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male
- Subjects :
- Male
Apolipoprotein B
Apolipoprotein E2
Epidemiology
Apolipoprotein E4
Apolipoprotein E3
lcsh:Medicine
Gallstones
Gastroenterology
Risk Factors
Odds Ratio
Protein Isoforms
lcsh:Science
Genetics
Multidisciplinary
Middle Aged
Phenotype
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Clinical Research Design
Subgroup analysis
Biology
Gallbladder Stone
Minimally Invasive Surgery
Asian People
Laparoscopic Surgery
Internal medicine
Gastrointestinal Surgery
medicine
Humans
Genetic Predisposition to Disease
Risk factor
Alleles
Polymorphism, Genetic
Models, Genetic
lcsh:R
Endoscopy
Odds ratio
medicine.disease
Confidence interval
Case-Control Studies
General Surgery
biology.protein
Genetic Polymorphism
lcsh:Q
Surgery
Meta-Analyses
Population Genetics
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....fb77c87cf72d5cfac8bc964acf0e79cb