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The Effectiveness of Different Doses of Intravenous Immunoglobulin on Severe Hand, Foot and Mouth Disease: A Meta-Analysis
- Source :
- Medical Principles and Practice. 28:256-263
- Publication Year :
- 2019
- Publisher :
- S. Karger AG, 2019.
-
Abstract
- Objective: To conduct a meta-analysis of evidence from randomized controlled trails (RCTs) of different doses of intravenous immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) to provide the scientific basis for clinical practice. Methods: A search of PubMed-Medline, CNKI, Wanfang, and VIP database (until June 30, 2017) was performed and Software RevMan5.3 was used to evaluate the effect of different doses of IVIG on HFMD in RCTs. We used random-effects models (or fixed-effects models) and generic inverse variance methods to process quantitative data, followed by a leave-one-out method for sensitivity analysis. Results: From a total of 420 entries identified via searches, 8 RCTs involving 1,450 patients were included in the final analysis. The results of the meta-analysis showed that compared with conventional therapy alone, conventional therapy combined with IVIG had shorter fever clearance time, shorter rash regression time, and shorter clinical cure time. Subgroup analyses showed that the high-dose group (1 g/kg/day) had shorter fever clearance time (p < 0.05), shorter rash regression (p< 0.05), shorter remission time of neurological symptoms (p < 0.05), but longer clinical cure time (p > 0.05). Conclusion: The high-dose group has a better prognosis; however, the advantages and disadvantages should be carefully considered when deciding the doses in the treatment of severe HFMD.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Fever
020205 medical informatics
02 engineering and technology
Severity of Illness Index
Hand-foot-and-mouth disease
03 medical and health sciences
Internal medicine
0202 electrical engineering, electronic engineering, information engineering
medicine
Humans
Child
Randomized Controlled Trials as Topic
Original Paper
Dose-Response Relationship, Drug
Foot-and-mouth disease
biology
business.industry
Remission Induction
Immunoglobulins, Intravenous
Infant
General Medicine
Exanthema
medicine.disease
Combined Modality Therapy
Rash
Clearance time
Clinical Practice
Child, Preschool
Meta-analysis
biology.protein
Female
030101 anatomy & morphology
medicine.symptom
Antibody
Hand, Foot and Mouth Disease
business
Cure time
Subjects
Details
- ISSN :
- 14230151 and 10117571
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Medical Principles and Practice
- Accession number :
- edsair.doi.dedup.....fb791bc63d5b34c2dbbb7f2e8c8e901d