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Biliary Tract Cancer: Epidemiology, Radiotherapy, and Molecular Profiling
- Source :
- American Society of Clinical Oncology Educational Book. :e194-e203
- Publication Year :
- 2016
- Publisher :
- American Society of Clinical Oncology (ASCO), 2016.
-
Abstract
- Biliary tract cancer, or cholangiocarcinoma, arises from the biliary epithelium of the small ducts in the periphery of the liver (intrahepatic) and the main ducts of the hilum (extrahepatic), extending into the gallbladder. The incidence and epidemiology of biliary tract cancer are fluid and complex. It is shown that intrahepatic cholangiocarcinoma is on the rise in the Western world, and gallbladder cancer is on the decline. Radiation therapy has emerged as an important component of adjuvant therapy for resected disease and definitive therapy for locally advanced disease. The emerging sophisticated techniques of imaging tumors and conformal dose delivery are expanding the indications for radiotherapy in the management of bile duct tumors. As we understand more about the molecular pathways driving biliary tract cancers, targeted therapies are at the forefront of new therapeutic combinations. Understanding the gene expression profile and mutational burden in biliary tract cancer allows us to better discern the pathogenesis and identify promising new developmental therapeutic targets.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
medicine.medical_treatment
Cholangiocarcinoma
03 medical and health sciences
0302 clinical medicine
Adjuvant therapy
medicine
Humans
Molecular Targeted Therapy
Gallbladder cancer
Intrahepatic Cholangiocarcinoma
Biliary tract neoplasm
Bile duct
business.industry
Gallbladder
General Medicine
medicine.disease
Neoplasm Proteins
Radiation therapy
Biliary Tract Neoplasms
030104 developmental biology
medicine.anatomical_structure
Biliary tract
030220 oncology & carcinogenesis
Gallbladder Neoplasms
business
Signal Transduction
Subjects
Details
- ISSN :
- 15488756 and 15488748
- Database :
- OpenAIRE
- Journal :
- American Society of Clinical Oncology Educational Book
- Accession number :
- edsair.doi.dedup.....fba75fdd063f31928ba0fbe9bd37e1b4
- Full Text :
- https://doi.org/10.1200/edbk_160831