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Identifying the Phenotypic and Temporal Heterogeneity of Knee Osteoarthritis: Data From the Osteoarthritis Initiative
- Source :
- Frontiers in Public Health, Vol 9 (2021), Frontiers in Public Health
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Objective: Previous studies discussing phenotypic and temporal heterogeneity of knee osteoarthritis (KOA) separately have fatal limitations that either clustering patients with similar severity or assuming all knees have a single common progression pattern, which are unreliable. This study tried to uncover more reliable information on phenotypic and temporal heterogeneity of KOA.Design: Data were from Osteoarthritis Initiative database. Six hundred and seventy-eight unilateral knees that have greater Kellgren and Lawrence (KL) grade than the contralateral knees at baseline and in all follow-up 48 months were included. Measurements of biomarkers at baseline were chosen. Subtype and Stage Inference model (SuStaIn) was applied as a subtype-progression model to identify subtypes, subtype biomarker progress sequences and stages of KOA.Results: This study identified three subtypes which account for 15, 61, and 24% of knees, respectively. Each subtype has distinct subtype biomarker progress sequence. For knees with KL grade 0/1, 2, 3, and 4, they have different distributions on stage and 26, 53, 89, and 95% of them are strongly assigned to subtypes. When assessing whether a knee has KL (grade ≥ 2), subtypes and stages from subtypes-progression model (SuStaIn) are significantly better fitting than those from subtypes-only (mixture of Gaussians) (likelihood ratio = 105.59, p = 2.2 × 10−16) or stages-only (SuStaIn where setting c = 1) (likelihood ratio = 58.04, p = 2.57 × 10−14) model. Stages in subtypes-progression model has greater β than stages-only model. Subtypes from subtypes-progression model have no statistical significance.Conclusions: For subtypes-progression model, stages contain more complete temporal information and subtypes are closer to real OA subtypes.
- Subjects :
- Oncology
medicine.medical_specialty
Knee Joint
phenotype
Osteoarthritis
subtype
Temporal heterogeneity
Internal medicine
Statistical significance
medicine
Humans
trajectories
Knee
Stage (cooking)
Temporal information
Original Research
business.industry
Public Health, Environmental and Occupational Health
Osteoarthritis, Knee
medicine.disease
Phenotype
osteoarthritis
Disease Progression
Biomarker (medicine)
Public Health
progression
Public aspects of medicine
RA1-1270
business
Subjects
Details
- Language :
- English
- ISSN :
- 22962565
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Public Health
- Accession number :
- edsair.doi.dedup.....fba85f76d32af1260bbfbb1528242610
- Full Text :
- https://doi.org/10.3389/fpubh.2021.726140/full