Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus ?

Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145–155) of TGEV may result both in the loss of the sialic acid binding acitivity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding acitivity is involved in the enteropathogenicity of TGEV On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stabiltiy. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.