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Primary Sjogren's syndrome in men
- Source :
- Scandinavian Journal of Rheumatology, Scandinavian Journal of Rheumatology, Taylor & Francis, 2008, 37 (4), pp.300-5. ⟨10.1080/03009740802001426⟩
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; OBJECTIVE: To determine whether there were any clinical and biological differences between male and female patients with primary Sjogren's syndrome (pSS) in a large bicentric series of patient. METHODS: We studied 419 consecutive patients (mean age at onset 53.6 years, mean disease outcome 73 months) with pSS according to American-European criteria, attending two different Departments of Internal Medicine in France. The 42 (9%) male patients in this cohort comprised the male group described in this study. RESULTS: Extraglandular manifestations during the course of the disease were present in 37 (89%) of our male patients with pSS. The extraglandular manifestations were similar among the two groups except that the male patients showed a lower frequency of depression or asthaenia (5% vs. 20%, p = 0.014) compared with the females. A significantly greater percentage of women reported lymphopaenia (26% vs. 8%, p = 0.02) and leucopaenia (18% vs. 3%, p = 0.015) at onset, but thrombopaenia was more common in the male patients (21% vs. 6%, p = 0.001). Lymphoma development was slightly more common in the male patients, but with no statistical significance (10% vs. 3%, p = 0.06), and occurred earlier after the SS diagnosis (log rank test p = 0.04). CONCLUSION: Although pSS is typically a disease affecting women, clinicians should be aware that it may be diagnosed in male patients. Except for haematological presentation, we could not find any notable differences in clinical and immunological characteristics between male and female patients with pSS.
- Subjects :
- Male
Pediatrics
Systemic disease
0302 clinical medicine
MESH: Aged, 80 and over
Sex factors
Immunopathology
Immunology and Allergy
Aged, 80 and over
MESH: Aged
0303 health sciences
MESH: Middle Aged
Follow up studies
General Medicine
MESH: Follow-Up Studies
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
3. Good health
Sjogren's Syndrome
Female
Adult
musculoskeletal diseases
medicine.medical_specialty
Immunology
03 medical and health sciences
Sex Factors
stomatognathic system
Rheumatology
MESH: Sex Factors
Internal medicine
Female patient
medicine
Humans
Aged
030304 developmental biology
030203 arthritis & rheumatology
Autoimmune disease
MESH: Humans
business.industry
MESH: Adult
medicine.disease
eye diseases
MESH: Male
stomatognathic diseases
MESH: Sjogren's Syndrome
Sjogren s
business
MESH: Female
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 03009742
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Rheumatology, Scandinavian Journal of Rheumatology, Taylor & Francis, 2008, 37 (4), pp.300-5. ⟨10.1080/03009740802001426⟩
- Accession number :
- edsair.doi.dedup.....fbca7fb1259ed03fa478e4172593c5ab
- Full Text :
- https://doi.org/10.1080/03009740802001426⟩