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Preoperative Anemia or Low Hemoglobin Predicts Poor Prognosis in Gastric Cancer Patients: A Meta-Analysis
- Source :
- Disease Markers, Vol 2019 (2019), Disease Markers
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Background. The prognostic value of preoperative anemia in gastric cancer remains unclear. Therefore, the purpose of the present study is to evaluate the prognostic value of preoperative anemia in gastric cancer. Methods. We searched Embase and PubMed databases for relevant studies from inception to March 2018. The prognostic value of preoperative anemia in gastric cancer was determined by calculating the hazard ratio (HR) and the corresponding 95% confidence interval (CI) as effect measures. A random effect model was used in cases in which there was significant heterogeneity; otherwise, a fixed effect model was used. Statistical analyses were performed using Stata software. Results. Seventeen studies involving 13,154 gastric cancer patients were included. The estimated rate of preoperative anemia was 36% (95%CI=27-44%). The overall survival of preoperative anemia was poor (HR=1.33, 95%CI=1.21-1.45). Moreover, disease-free survival was significantly lower in patients with preoperative anemia compared with those without this condition (HR=1.62, 95%CI=1.13-2.32). These findings were corroborated by the results of subgroup analyses. Conclusions. The results indicate that preoperative anemia predicts poor prognosis in gastric cancer, including overall survival and disease-free survival. Therefore, preoperative anemia may be a convenient and cost-effective blood-derived prognostic marker for gastric cancer.
- Subjects :
- medicine.medical_specialty
Poor prognosis
Clinical Biochemistry
Review Article
Gastroenterology
Disease-Free Survival
03 medical and health sciences
Hemoglobins
0302 clinical medicine
Stomach Neoplasms
Internal medicine
Genetics
medicine
Overall survival
Humans
Preoperative anemia
Low hemoglobin
Molecular Biology
lcsh:R5-920
business.industry
Biochemistry (medical)
Hazard ratio
Cancer
Anemia
General Medicine
medicine.disease
Confidence interval
030220 oncology & carcinogenesis
Meta-analysis
Preoperative Period
030211 gastroenterology & hepatology
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 18758630 and 02780240
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- Disease Markers
- Accession number :
- edsair.doi.dedup.....fbcc98caa1cc0eac4f4b497a9afce1a2