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Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy
- Source :
- International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 19836-19850 (2015), International Journal of Molecular Sciences
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Mitochondria are important cellular organelles that function as control centers of the energy supply for highly proliferative cancer cells and regulate apoptosis after cancer chemotherapy. Cisplatin is one of the most important chemotherapeutic agents and a key drug in therapeutic regimens for a broad range of solid tumors. Cisplatin may directly interact with mitochondria, which can induce apoptosis. The direct interactions between cisplatin and mitochondria may account for our understanding of the clinical activity of cisplatin and development of resistance. However, the basis for the roles of mitochondria under treatment with chemotherapy is poorly understood. In this review, we present novel aspects regarding the unique characteristics of the mitochondrial genome in relation to the use of platinum-based chemotherapy and describe our recent work demonstrating the importance of the mitochondrial transcription factor A (mtTFA) expression in cancer cells.
- Subjects :
- Mitochondrial DNA
medicine.medical_treatment
cisplatin
Antineoplastic Agents
Review
Biology
Mitochondrion
Catalysis
cancer chemotherapy
Mitochondrial Proteins
Inorganic Chemistry
lcsh:Chemistry
Neoplasms
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Transcription factor
lcsh:QH301-705.5
Spectroscopy
Cisplatin
Chemotherapy
mtDNA
Organic Chemistry
General Medicine
TFAM
Mitochondria
Computer Science Applications
Cell biology
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Oxidative Stress
lcsh:Biology (General)
lcsh:QD1-999
Drug Resistance, Neoplasm
Apoptosis
Genome, Mitochondrial
Cancer cell
prognosis
mtTFA
DNA Damage
Transcription Factors
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....fbd44f7bf4e9db03ce65f3461150751c