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Quantification of metabolites from single-voxel in vivo 1H NMR data of normal human brain by means of time-domain data analysis
- Source :
- Magma (New York, N.Y.). 3(3-4)
- Publication Year :
- 1995
-
Abstract
- We present here a combination of time-domain signal analysis procedures for quantification of human brain in vivo 1H NMR spectroscopy (MRS) data. The method is based on a separate removal of a residual water resonance followed by a frequency-selective time-domain line-shape fitting analysis of metabolite signals. Calculation of absolute metabolite concentrations was based on the internal water concentration as a reference. The estimated average metabolite concentrations acquired from six regions of normal human brain with a single-voxel spin-echo technique for the N-acetylaspartate, creatine, and choline-containing compounds were 11.4 +/- 1.0, 6.5 +/- 0.5, and 1.7 +/- 0.2 mumol kg-1 wet weight, respectively. The time-domain analyses of in vivo 1H MRS data from different brain regions with their specific characteristics demonstrate a case in which the use of frequency-domain methods pose serious difficulties.
- Subjects :
- 1h nmr spectroscopy
Aspartic Acid
Magnetic Resonance Spectroscopy
Radiological and Ultrasound Technology
Single voxel
Metabolite
Biophysics
Brain
Signal Processing, Computer-Assisted
Human brain
Creatine
Choline
chemistry.chemical_compound
Nuclear magnetic resonance
medicine.anatomical_structure
chemistry
In vivo
Proton NMR
medicine
Humans
Radiology, Nuclear Medicine and imaging
Time domain
Protons
Subjects
Details
- ISSN :
- 09685243
- Volume :
- 3
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Magma (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....fbece2bc5f2e7fa09478287c4be96385