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Protein Tyrosine Phosphatase 1B, a Major Regulator of Leptin-Mediated Control of Cardiovascular Function
- Source :
- Circulation. 120:753-763
- Publication Year :
- 2009
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2009.
-
Abstract
- Background— Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target in the treatment of obesity and type II diabetes mellitus, constrains the metabolic actions of leptin, but the extent to which PTP1B regulates its cardiovascular effects is unclear. This study examined the hypothesis that PTP1B is a negative regulator of the cardiovascular effects of leptin. Methods and Results— PTP1B knockout mice had lower body fat but higher mean arterial pressure (116±5 versus 105±5 mm Hg, P P P P 1 -adrenergic receptor subtypes, consistent with blunted constriction to phenylephrine. Conclusions— These data indicate that PTP1B is a key regulator of the cardiovascular effects of leptin and that reduced vascular adrenergic reactivity provides a compensatory limit to the effects of leptin on mean arterial pressure.
- Subjects :
- Leptin
Male
medicine.medical_specialty
Mean arterial pressure
Sympathetic Nervous System
Blood Pressure
Type 2 diabetes
Protein tyrosine phosphatase
Article
Mice
Phenylephrine
Stress, Physiological
Receptors, Adrenergic, alpha-1
Physiology (medical)
Diabetes mellitus
Internal medicine
medicine
Animals
Vasoconstrictor Agents
Obesity
Adrenergic alpha-Antagonists
Aorta
Mice, Knockout
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Mice, Inbred BALB C
business.industry
Prazosin
medicine.disease
Phenotype
Blood pressure
Endocrinology
Vasoconstriction
Hypertension
Knockout mouse
medicine.symptom
Cardiology and Cardiovascular Medicine
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....fc004ea89422d4202456293beefdbd92