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The FTO Gene Is Associated With Adulthood Obesity in the Mexican Population
- Source :
- Obesity. 16:2296-2301
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations. In the present study, we explored the association of FTO gene polymorphisms with obesity and other biochemical parameters in the Mexican population. We also assessed FTO gene expression levels in adipose tissue of obese and nonobese individuals. The study comprised 788 unrelated Mexican-Mestizo individuals and 31 subcutaneous fat tissue biopsies from lean and obese women. FTO single-nucleotide polymorphisms (SNPs) rs9939609, rs1421085, and rs17817449 were associated with obesity, particularly with class III obesity, under both additive and dominant models (P = 0.0000004 and 0.000008, respectively). These associations remained significant after adjusting for admixture (P = 0.000003 and 0.00009, respectively). Moreover, risk alleles showed a nominal association with lower insulin levels and homeostasis model assessment of B-cell function (HOMA-B), and with higher homeostasis model assessment of insulin sensitivity (HOMA-S) only in nonobese individuals (P (dom) = 0.031, 0.023, and 0.049, respectively). FTO mRNA levels were significantly higher in subcutaneous fat tissue of class III obese individuals than in lean individuals (P = 0.043). Risk alleles were significantly associated with higher FTO expression in the class III obesity group (P = 0.047). In conclusion, FTO is a major risk factor for obesity (particularly class III) in the Mexican-Mestizo population, and is upregulated in subcutaneous fat tissue of obese individuals.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Subcutaneous Fat
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Medicine (miscellaneous)
Adipose tissue
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Risk Assessment
FTO gene
Endocrinology
Gene Frequency
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Genetic Predisposition to Disease
Obesity
RNA, Messenger
education
Mexico
education.field_of_study
Nutrition and Dietetics
Class III obesity
business.industry
Proteins
nutritional and metabolic diseases
Middle Aged
medicine.disease
Up-Regulation
Diabetes Mellitus, Type 2
Female
business
Subjects
Details
- ISSN :
- 19307381
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi.dedup.....fc08698ce7181af84cd909775d878a5d