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Clinicopathological features and prognosis of patients with pregnancy-associated breast cancer: A matched case control study
- Source :
- Asia-Pacific Journal of Clinical Oncology
- Publication Year :
- 2019
-
Abstract
- Aim We aimed to clarify tumor features and prognosis of pregnancy‐associated breast cancer (PABC) among Chinese women. Methods PABC was defined as breast cancer diagnosed during pregnancy or within a year after delivery. Patients with PABC were selected from breast cancer cases of women ≤45 years treated at our institution between December 2012 and December 2017, and one non‐PABC control was matched for stage, age, and year of diagnosis for each case. Results Forty‐one women with PABC were identified (22 diagnosed during pregnancy and 19 within 1 year of delivery). There were significantly more progesterone receptor (PR)‐ and triple‐negative tumors in the PABC (56.1% and 24.4%, respectively) than in the non‐PABC group (31.7% and 4.9%, respectively) (P = .045 and .026, respectively). Human epidermal growth factor receptor 2 positivity was the same in both groups (31.7%). Median disease‐free survival (DFS) was 29.0 months (95% confidence interval [CI], 6.5‐51.5 months) in the PABC and 40.9 months (95% CI, 22.8‐58.8 months) in the non‐PABC group (P = .167). Median overall survival (OS) was 82.8 months in the PABC (95% CI, 39.3‐126.5 months) versus 80.1 months (95% CI, 56.7‐103.6 months) in the non‐PABC group (P = .131). Conclusion Histological features were similar in both groups, except that PR‐ and triple‐negative tumors were more frequent in the PABC group. Survival analyses show similar OS for patients with PABC and non‐PABC. DFS tended to be shorter in the PABC group; however, this difference was not statistically significant.<br />After matching PABC cases with non‐PABC cases for stage and age (±1 year), as well as year of diagnosis secondarily (±1 year),on survival analysis, the median DFS tended to be shorter in women with PABC than in non‐PABC; however, this difference was not statistically significant and the median OS of the two groups were almost the same.
- Subjects :
- Adult
medicine.medical_specialty
Breast Neoplasms
Disease-Free Survival
03 medical and health sciences
Young Adult
0302 clinical medicine
Breast cancer
breast cancer
Pregnancy
Progesterone receptor
medicine
Humans
030212 general & internal medicine
postpartum
Stage (cooking)
Human Epidermal Growth Factor Receptor 2
Obstetrics
business.industry
Case-control study
General Medicine
Original Articles
medicine.disease
Prognosis
Confidence interval
Oncology
030220 oncology & carcinogenesis
Case-Control Studies
Clinicopathological features
Female
Original Article
business
Pregnancy Complications, Neoplastic
clinicopathological features
Subjects
Details
- ISSN :
- 17437563
- Volume :
- 17
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Asia-Pacific journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....fc14d8100cca553680ef5eb918f3f71f