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The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing
- Source :
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:323-332
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Background Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared with healthy control subjects (HCs) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study investigates the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD. Methods In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD. Results Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] .057). Conclusions This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies.
- Subjects :
- Male
medicine.medical_specialty
Cognitive Neuroscience
Emotions
Hippocampus
Audiology
behavioral disciplines and activities
Amygdala
050105 experimental psychology
Disease course
03 medical and health sciences
0302 clinical medicine
Limbic system
mental disorders
Limbic System
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Biological Psychiatry
Depression (differential diagnoses)
Depressive Disorder, Major
medicine.diagnostic_test
business.industry
05 social sciences
medicine.disease
Magnetic Resonance Imaging
Cross-Sectional Studies
medicine.anatomical_structure
nervous system
Major depressive disorder
Female
Neurology (clinical)
Functional magnetic resonance imaging
business
Insula
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 24519022
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Accession number :
- edsair.doi.dedup.....fc23cdb69125dea4a1fe80bd46c8a42e