Increased density of glutamate/N-methyl-d-aspartate receptors in putamen from schizophrenic patients

Saturable radioligand binding of [3H]L-689,560 to the glycine site of the N-methyl-D-aspartate (NMDA) glutamate receptor complex was employed to determine the density of this receptor in putamen, caudate and nucleus accumbens taken post mortem from schizophrenic patients and matched controls. Receptor density was found to be significantly increased in putamen of schizophrenics (P=0.012), although no significant change was found in the other two areas studied. Further experiments following 21 days administration of haloperidol to rats provided no evidence that the increase was related to prior drug treatment.