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Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice
- Source :
- Journal of Radiation Research
- Publication Year :
- 2013
- Publisher :
- Oxford University Press, 2013.
-
Abstract
- Previous in vitro and in vivo studies showed that sodium orthovanadate (vanadate), an inorganic vanadium compound, could effectively suppress radiation-induced p53-mediated apoptosis via both transcription-dependent and transcription-independent pathways. As a potent radiation protector administered at a dose of 20 mg/kg body weight (20 mg/kg) prior to total-body irradiation (TBI) by intra-peritoneal (ip) injection, it completely protected mice from hematopoietic syndrome and partially from the gastrointestinal syndrome. In the present study, radiation mitigation effects from vanadate were investigated by ip injection of vanadate after TBI in mice. Results showed that a single administration of vanadate at a dose of 20 mg/kg markedly improved the 30-day survival and the peripheral blood hemogram, relieved bone marrow aplasia and decreases occurrence of the bone marrow micronucleated erythrocytes in the surviving animals. The dose reduction factor was 1.2 when a single dose of 20 mg/kg was administrated 15 minutes after TBI in mice using the 30-day survival test as the endpoint. Results also showed that either doubling the vanadate dose (40 mg/kg) in a single administration or continuing the vanadate treatment (after a single administration at 20 mg/kg) from the following day at a dose of 5 mg/kg per day for 4 consecutive days would further significantly improved the efficacy for rescuing bone marrow failure in the 30-day survival test. Taken together, these findings indicate that vanadate would be a potent mitigator suppressing the acute lethality (hematopoietic syndrome) and minimizing the detrimental effects (anhematopoiesis and delayed genotoxic effects) induced by TBI in mice.
- Subjects :
- mice
Erythrocytes
Time Factors
Health, Toxicology and Mutagenesis
Hematopoietic System
Radiation-Protective Agents
Bone Marrow Aplasia
Pharmacology
radiation-induced hematopoietic syndrome
bone marrow micronucleated erythrocytes
chemistry.chemical_compound
In vivo
Bone Marrow
medicine
Animals
Radiology, Nuclear Medicine and imaging
Vanadate
Radiation Injuries
Sodium orthovanadate
Biology
Mice, Inbred ICR
Radiation
Micronucleus Tests
Chemistry
X-Rays
Bone marrow failure
mitigator
Total body irradiation
medicine.disease
Hematopoietic Stem Cells
medicine.anatomical_structure
Immunology
Micronucleus test
Female
Bone marrow
Tumor Suppressor Protein p53
Vanadates
Whole-Body Irradiation
Subjects
Details
- Language :
- English
- ISSN :
- 13499157 and 04493060
- Volume :
- 54
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Radiation Research
- Accession number :
- edsair.doi.dedup.....fc3458869e5c39f4c444c0167ddacdf4