Back to Search
Start Over
Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems
- Source :
- Trends in cardiovascular medicine. 18(4)
- Publication Year :
- 2008
-
Abstract
- For development of a new ligand-directed pharmacology, it is critical to measure delivery of targeted drug ligands via molecular imaging or diagnostic readouts (termed theranostics). Combinatorial peptide libraries serve as unbiased functional screens that can identify specific peptides targeting cell-surface receptors accessible to the circulation. As candidate drug leads, such peptides provide motifs likely to modify ligand-receptor interactions and downstream signal transduction pathways. This strategy is synergistic with genomic and proteomic approaches and has yielded insights into the specialized nature of the target tissue microenvironment. However, for this vision to be realized, one must look, as recent literature suggests, beyond receptor levels and critically analyze ligand accessibility as a key determinant in pharmacodelivery systems.
- Subjects :
- Ligand
Receptor expression
Target tissue
Molecular Probe Techniques
Angiogenesis Inhibitors
Receptors, Cell Surface
Computational biology
Biology
Bioinformatics
Ligands
Aminopeptidases
Drug Delivery Systems
Peptide Library
Drug Design
Animals
Humans
Relevance (information retrieval)
Molecular imaging
Signal transduction
Cardiology and Cardiovascular Medicine
Receptor
Subjects
Details
- ISSN :
- 10501738
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Trends in cardiovascular medicine
- Accession number :
- edsair.doi.dedup.....fc43b1c40fac64c94db391126d48b7d2