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Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas
- Source :
- Biochemical and biophysical research communications. 252(1)
- Publication Year :
- 1998
-
Abstract
- The effects of the imidazoline compound RX871024 on arginine-induced insulin, glucagon, and somatostatin secretion in the isolated perfused rat pancreas have been investigated. Arginine induced biphasic insulin, glucagon, and somatostatin release when infused for 20 min at 20 mM concentration and 3.3 mM glucose in the medium. RX871024, at 10 microM, did not influence basal hormone secretion but enhanced arginine-stimulated insulin and somatostatin release. In contrast, glucagon secretion was markedly inhibited by 10 microM imidazoline. RX871024 (1 microM) did not significantly affect arginine-induced insulin and somatostatin secretion but had an inhibitory effect on the second phase of glucagon release. In conclusion, RX871024 exerts a complex effect on the endocrine pancreas challenged by arginine, comprising stimulation of insulin and somatostatin release and inhibition of glucagon release. These effects on hormone release probably constitute the main mechanism of the antidiabetogenic action of the imidazolines.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Indoles
Time Factors
Arginine
Somatostatin secretion
medicine.medical_treatment
Biophysics
Imidazoline receptor
In Vitro Techniques
Biochemistry
Glucagon
Islets of Langerhans
Internal medicine
Insulin Secretion
medicine
Animals
Insulin
Rats, Wistar
Molecular Biology
Pancreas
Chemistry
Glucagon secretion
Imidazoles
Cell Biology
Rats
Perfusion
Kinetics
Endocrinology
medicine.anatomical_structure
Somatostatin
Female
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 252
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....fc45b64b96291ec94c077a7c5bee3d50