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Early Gastrointestinal Regulatory Peptide Response to Intestinal Resection in the Rat Is Stimulated by Enteral Glutamine Supplementation
- Source :
- Digestive Surgery. 16:197-203
- Publication Year :
- 1999
- Publisher :
- S. Karger AG, 1999.
-
Abstract
- Background: Intestinal resection stimulates the synthesis and release of gastrointestinal peptides that regulate the growth and adaptation of the mucosa. Luminal nutrients are necessary for optimal proliferation and glutamine is the preferential nutrient to the small bowel. The interplay between glutamine and regulatory peptides could be important in treating short bowel syndrome. Methods: 63 Sprague-Dawley rats were divided into 3 groups: resection; transection, or controls. After intestinal resection animals were orally fed either a diet without glutamine or a glutamine-supplemented diet for 2 days. Transected animals and controls without prior surgery were fed the same two diets. Epidermal growth factor (EGF), transforming growth factor-α, insulin-like growth factors I and II (IGF-I and IGF-II), peptide YY (PYY), and enteroglucagon were analyzed in mucosa from the proximal jejunum, distal ileum as well as in portal plasma when the animals were euthanized 72 h after surgery. Results: Intestinal resection resulted in an early increase in portal plasma concentrations of PYY, EGF, enteroglucagon, and mucosal IGF-II and EGF content that were significant in glutamine-treated animals. Glutamine significantly increased PYY in portal blood after resection (p < 0.05). Conclusion: Glutamine could be of importance for the functional adaptation of residual small bowel mucosa by increasing PYY release.
- Subjects :
- Male
medicine.medical_specialty
Glutamine
Glucagon-Like Peptides
Enteroglucagon
Regulatory peptide
Enteral administration
Gastrointestinal Hormones
Rats, Sprague-Dawley
Insulin-Like Growth Factor II
Epidermal growth factor
Internal medicine
Animals
Medicine
Peptide YY
Insulin-Like Growth Factor I
Intestinal Mucosa
Epidermal Growth Factor
business.industry
Gastroenterology
Transforming Growth Factor alpha
Rats
Intestines
Endocrinology
Glutamine supplementation
Surgery
Intestinal resection
business
Subjects
Details
- ISSN :
- 14219883 and 02534886
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Digestive Surgery
- Accession number :
- edsair.doi.dedup.....fc4b9062c5dada5f8f7855758e8a85a0