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A Proteomics Approach to Identify Protein Expression Changes in Rat Liver Following Administration of 3,5,3‘-Triiodo-<scp>l</scp>-thyronine
- Source :
- Journal of Proteome Research. 5:2317-2327
- Publication Year :
- 2006
- Publisher :
- American Chemical Society (ACS), 2006.
-
Abstract
- We analyzed whole cell protein content of rat liver following T3 administration. Fourteen differentially expressed proteins were unambiguously identified and were involved in substrates and lipid metabolism, energy metabolism, detoxification of cytotoxic products, calcium homeostasis, amino acid catabolism, and the urea cycle. This study represents the first systematic identification of T3-induced changes in liver protein expression profile and provides novel information at the molecular, cellular, and tissue level of T3 action We analyzed whole cell protein content of rat liver following T3 administration. Fourteen differentially expressed proteins were unambiguously identified and were involved in substrates and lipid metabolism, energy metabolism, detoxification of cytotoxic products, calcium homeostasis, amino acid catabolism, and the urea cycle. This study represents the first systematic identification of T3-induced changes in liver protein expression profile and provides novel information at the molecular, cellular, and tissue level of T3 action. © 2006 American Chemical Society.
- Subjects :
- Male
Proteomics
Biology
Biochemistry
triiodothyronine
liver
thyroid hormone action
chemistry.chemical_compound
Detoxification
Animals
Electrophoresis, Gel, Two-Dimensional
Rats, Wistar
DNA Primers
Calcium metabolism
chemistry.chemical_classification
Reverse Transcriptase Polymerase Chain Reaction
Catabolism
Proteins
Lipid metabolism
General Chemistry
Rats
Amino acid
Gene Expression Regulation
Liver
chemistry
Urea cycle
Thyronine
Triiodothyronine
Thyroid hormone action
Subjects
Details
- ISSN :
- 15353907 and 15353893
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Proteome Research
- Accession number :
- edsair.doi.dedup.....fc65f41e93b054c07d20f2644a905052